Tag Archives: Photodynamic therapy

mesothelioma surgery and photodynamic therpay

I notice this is starting to get more and more coverage, I have never come across photodynamic therapy  being used in the UK, so assume it is only in the US at the moment.

Dr. Joseph S. Friedberg, a top thoracic surgeon at the Hospital of the University of Pennsylvania in Philadelphia, instead of removing the lung, stripped the lung of its tumor then hit residual malignant cells with photodynamic therapy. The result hasn’t been earth-shattering, says Friedberg, but it has bought dozens of malignant mesothelioma patients extra months and even years as well as the ability to better fight the cancer when it recurs.

According to an article in the Philadelphia Inquirer, two years after receiving this type of treatment for their pleural mesothelioma, 27 of the surgeon’s 38 patients are still alive. That’s a whopping 71 percent, a figure that thrills Dr. Friedberg, whose study was just published in The Annals of Thoracic Surgery. The publication had turned down the study the first time it was submitted, with reviewers saying the follow-up time was too short and that the authors were overestimating the projected survival time.

So he performed the procedure on more seriously ill mesothelioma patients and the results continue to be impressive in comparison to survival rates for patients who have undergone more conventional treatments such as chemotherapy and radiation.Friedberg believes that the light therapy used after the tumor has been removed plays the major role in extending the lives of his patients. He believes it “primes the immune system” and helps it keep any recurring cancer under control. “The cancer comes back more like a house cat than a tiger,” he stresses.

Complications can still occur and the recurring cancer may eventually win, but median survival for the 38 patients Friedberg’s team treated from 2004 through 2010 was 31.7 months even though the cancer came back in a median time of 9.6 months. Friedberg and his team at the University of Pennsylvania Cancer Center are gunning for asurvival rate of 10 years and are currently searching for better photosensitizers and safer ways to deliver the laser light energy.

“I’d be happy to turn this into a chronic disease, like diabetes,” Friedberg noted. “My goal for my career is to make it truly better for these patients. That’s what I want to do for the rest of my life.”

Here’s hoping from all of us that he gets achieves this goal – would be good to know if anyone has heard of this being used in the  UK

Read more: http://www.mesothelioma.com/news/2012/06/penn-surgeons-lung-sparing-surgery-making-headway-against-mesothelioma.htm#ixzz1zUwHGhZN

Photodynamic therapy and mesothelioma treatment


Illinois-based Pinnacle Biologics have announced  they are applying for orphan drug status for their product Photofrin® (porfimer sodium), which they believe will prove to be a successful adjuvant to surgery for individuals suffering from malignant pleural mesothelioma.

According to the company, the drug is used in photodynamic therapy (PDT), a treatment procedure that has shown some success in treating mesothelioma patients. A two-stage process, PDT is accomplished by first injecting the Photofrin intravenously into the patient. About 40-50 hours later, patients are exposed to a non-burning laser light in the area of the tumor. The Photofrin is attracted to cancer cells and lingers in them. The light causes a biochemical reaction to occur in the cancer cells where the Photofrin remains, thus killing the cells.

Dr. Joseph S. Friedberg of the Department of Thoracic Surgery at Penn Presbyterian Medical Center in Philadelphia, has been experimenting with photodynamic therapy.

Friedberg said: “In studies completed at Penn, photodynamic therapy (PDT), in conjunction with surgery, has shown some very promising results for the treatment of mesothelioma. By utilizing PDT as an intraoperative treatment, we have been able to develop a technique where we can reliably preserve the patient’s lung. When compared to other treatments, this combination of lung-sparing surgery, PDT and standard chemotherapy appears to have a positive impact on both survival and quality of life. Based upon our clinical observations, characterizing the PDT effect and working on techniques to magnify it has become a major focus of our research.”